Liposarcoma Produced by 1:2-Benzpyrene

Tumours Produced in Hamsters by Benzpyrene

meantime by Gye and Foulds ( 1) no observations on this animal have been recorded. We used the Syrian, or golden, hamster ( Cricctus auratus), of which one strain is bred in our laboratory. Animals weighing about 80 gm. were injected subcutaneously, in the abdominal region, with benzpyrene Meurice, 0.25 C.C. of a solution in lard, every three or four weeks, the injections being interrupted as s...

IL-12 Produced by Dendritic Cells Augments

Gastric Absorption of 3,4-Benzpyrene

Lux UV with a Philora HPW 19@5-watt mercury vapor lamp). The intensity and the penetration power of the blue fluorescence was estimated by using an arbitrary gradation (cf. Fig. @). However, spectroscopic estimations were not made, and therefore it is unknown whether the blue fluores cence in the tissues depends on unchanged BP or on its blue fluorescent metabolites. Bearing this in mind, refer...

Inhibition of induction of benzpyrene hydroxylase by nickel carbonyl.

Exposure of rats to nickel carbonyl by inhalation (0.2 mg Ni/liter of air/15 min) or intravenous injection (2 mg Ni/100 gm) was found to inhibit the induction of benzpyrene hydroxylase in lung and liver. Phenothiazine induction and fluorometric measurements of benzpyrene hydroxylase were performed by the methods of Wattenberg and co-workers (31, 32). Benzpyrene hydroxylase activities in lungs a...

The role of heme synthesis during the induction of hepatic microsomal cytochrome P-450 and drug metabolism produced by benzpyrene.

6-Aminolevulinic acid synthetase, the initial and rate limiting step in hepatic heme synthesis, is induced by both benepyrene and phenobarbital. Induction of this enzyme by benzpyrene results in the stimulation of glycine-214C incorporation into hepatic microsomal heme in vivo and in the induction of -cytochrome P-450 and N-demethylase activity. 3-Amino-1,2,4-triazole, an inhibitor of the secon...